Selected Antimicrobial Information – Farm Animal
Amoxicillin [Farm Animal]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Cattle | Amoxi-Inject (Label dose)
For respiratory tract infections (shipping fever, pneumonia) due to Pasteurella multocida, P. hemolytica, Hemophilus species Staphylococci species, and Streptococci species and acute necrotic pododermatitis (foot rot) due to Fusobacterium necrophorum |
3-5 mg/lb (approx. 7-11 mg/kg) IM, SQ q 24h for up to 5 days |
| Amoxi-Mast (Label dose)
For the treatment of subclinical infectious bovine mastitis due to Streptococcus agalactiae and Staphylococcus aureus (penicillin sensitive) in lactating cattle
|
Administer after milking. Clean and disinfect the teat. Use one syringe per infected quarter q 12h for a maximum of 3 doses. | |
| Pre-Ruminating Cattle | Amoxi-Sol and Amoxi-Bol (Label dose)
For treatment of bacterial enteritis when due to susceptible Escherichia coli in pre-ruminating calves |
400 mg/100 lbs (approx. 9 mg/kg) PO q 12h daily. Treatment should be continued for 48 hours after all symptoms have subsided but not to exceed 5 days. |
| Swine | For the treatment of baby pigs under 10 pounds for porcine colibacillosis caused by Escherichia coli susceptible to amoxicillin | Administer 40 mg orally q 12h using a dosing pump. Treat animals for 48 hours after all symptoms have subsided but not beyond 5 days. |
Brand Name(s)
Amoxi-Mast, Amoxi-Bol, Amoxi-Sol , Amoxi-Inject, Amoxi-dose
Background
Amoxicillin is a bactericidal, time-dependent β-lactam antibiotic with improved activity against Gram-negative organisms when compared to penicillin, though with somewhat less activity against Gram-positive organisms. There is also some efficacy against anaerobes. Amoxicillin distributes widely through the plasma, and can cross the blood-brain barrier when meninges are inflamed although it is uncertain if therapeutic concentrations are achieved. It does not penetrate abscesses or sites of tissue necrosis well. Excretion is primarily as unchanged drug in urine.
Acceptable Uses
- In poultry, amoxicillin is used for the treatment of susceptible infections of the alimentary, urogenital and respiratory tracts
- In pigs, amoxicillin is used to treat major respiratory tract pathogens, mainly caused by Actinobacillus pleuropneumoniae, Streptococcus suis and Pasteurella multocida. Amoxicillin also is used against some digestive and urinary tract pathogens, such as Escherichia coli and Streptococcus suis
- In sheep, amoxicillin is used for the treatment of bacterial pneumonia due to Pasteurella spp. and Haemophilus spp.
- In goats, amoxicillin is indicated for the treatment of respiratory tract infections caused by, among other microorganisms,Mannheimia haemolytica, P. multocida, H. somnus, but not for penicillinase-producing S. aureus
- Amoxicillin also is used in pre-ruminating calves for treatment of bacterial enteritis due to E. coli, and in cattle for treatment of respiratory tract infections, including shipping fever and pneumonia due to P. multocida, M. haemolytica, Haemophilus spp., Streptococcus spp. andStaphylococcus spp., and for acute necrotic pododermititis (foot rot) due to Fusobacterium necrophorum
- Amoxicillin is also approved for use in lactating dairy cows by intramammary infusion with a suspension of amoxicillin trihydrate containing the equivalent of 62.5 mg of amoxicillin per disposable syringe for each infected quarter
Unacceptable Uses
Formulations Available
Notes
- For injectable amoxicillin in cattle:
- Treated animals must not be slaughtered for food during treatment and for 25 days after the last treatment.
- Milk from treated cows must not be used for human consumption during treatment or for 96 hours (8 milkings) after last treatment.
- Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- For Amoxi-Sol:
- Do not slaughter animals during treatment or for 20 days after the latest treatment.
- Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- For Amoxi-Doser:
- Do not slaughter during treatment or for 15 days after latest treatment.
- Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- For Amoxi-Mast:
- Do not use milk for food purposes if taken from treated animals within 60 hours (5 milkings) after last treatment.
- Do not slaughter treated animals for food purposes within 12 days after the last treatment.
- Federal law restricts this drug to use by or on the order of a licensed veterinarian.
