Search Results for: h5p
Juvenile Onset Chronic Kidney Disease (Juvenile Nephropathy)
JUVENILE-ONSET CHRONIC KIDNEY DISEASE Please note that the diseases and lesions discussed in this chapter might not always result in proteinuria. They are included here to provide a comprehensive overview of canine renal diseases. In our experience, diagnosis of juvenile onset kidney diseases is a common motivation for obtaining a renal biopsy. Some of the Read more »
Introduction
This Atlas of Renal Lesions in Proteinuric Dogs describes and illustrates the tissue abnormalities that are observed in, and therefore characterize, kidney diseases in dogs with renal proteinuria. These lesions can be identified when appropriate tissue specimens are adequately examined by experienced veterinary pathologists. Preparation of this atlas is another outcome of the World Small Animal Read more »
Tubular, Interstitial and Vascular Pathology seen with Glomerular Diseases
Tubular, interstitial and vascular injury often accompanies glomerular disease. In this context these three compartments should be carefully evaluated because the lesions that develop participate in the development of renal disease and can influences the clinical outcome. The morphological changes observed in the tubular, interstitial and vascular compartments are nonspecific and can also be recognized Read more »
Miscellaneous Glomerular Diseases
In addition to the common causes of proteinuric kidney disease in dogs, there are other patterns of glomerular injury that are rare or insufficiently characterized. With time, we hope to develop standardized criteria for diagnosis of these diseases and better understand their pathogeneses. Some of these diseases still have clinical features based on what we Read more »
Focal Segmental Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) describes both a disease entity characterized by primary injury to podocytes as well as a lesion that can occur secondarily in many types of chronic glomerular disease. As a disease entity, serial biopsies from FSGS patients (humans, dogs and cats) demonstrate disease progression with involvement of more and more glomeruli. Many Read more »
Membranoproliferative Glomerulonephritis
Membranoproliferative glomerulonephritis (MPGN) is a type of glomerular injury caused by immune-complex deposition on the luminal (subendothelial) surfaces of capillary walls and the resultant inflammatory response. Immune complex deposits are composed of mainly IgG and antigen. The source of the antigen is often suspected to be exogenous (associated with an infection). In some cases, the Read more »
Membranous Glomerulonephropathy
Membranous glomerulonephropathy (MGN) is an immune-complex mediated disease wherein immune complexes are deposited on the abluminal (subepithelial) side of the glomerular basement membrane (GBM). Immune complex deposits are composed of immunoglobulin (usually IgG) and antigen. The source of the antigen is often unknown and could be native or exogenous. Immune complex deposits activate the complement Read more »
Amyloidosis
Amyloid is the general term used for a wide variety of extracellular insoluble protein accumulations made of fibrils that have a β-pleated structure. In the kidney, amyloid is predominantly located in the glomeruli with fewer cases having interstitial or vascular amyloidosis. Histologic appearance – Nodular expansion of the mesangium and capillary walls by congophilic material Read more »