Selected Antimicrobial Information – Companion Animal
Tylosin [Companion]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Cats |
For upper respiratory tract infection | 6-16mg/kg PO q12h (extra-label use) |
| For campylobacteriosis | 11mg/kg PO q8h (extra-label use) | |
| For clostridial diarrhea | 20-40mg/kg PO q12-24h for 7-14d (extra-label use) | |
| For cryptosporidiosis | 10-15mg/kg PO q12h (extra-label use) | |
| Dogs |
For upper respiratory tract infection | 6-16mg/kg PO q12h (extra-label use) |
| For campylobacteriosis | 11mg/kg PO q8h (extra-label use) | |
| For clostridial diarrhea | 20-40mg/kg PO q12-24h for 7-14d (extra-label use) | |
| For inflammatory bowel disease | 12-20mg/kg PO q8-24h (gradually increase dosing interval) (extra-label use) | |
| For idiopathic antibiotic-responsive diarrhea | 6-16mg/kg PO q24h (extra-label use) |
Brand Name(s)
Tylan®
Background
Tylosin is a bacteriostatic, time-dependent macrolide antibiotic with good activity against Gram-positive aerobes. There is somewhat less activity against Gram-negative aerobes, but good activity against Pasteurellaceae. Tylosin is not effective against Pseudomonas aeruginosa and most Enterococcus spp. Distribution is wide, and excretion is primarily as unchanged drug in bile and urine.
Acceptable Uses
- Treatment of campylobacteriosis, clostridial diarrhea, or cryptosporidioisis.
- Treatment of upper respiratory tract disease associated with Mycoplasma or Chlamydia spp.
- Control (but not necessarily cure) of inflammatory bowel disease or idiopathic antibiotic-responsive diarrhea.
Unacceptable Uses
- Low doses of tylosin was previously used to prevent or reduce tear-staining (secondary to epiphora). This is now considered irresponsible antimicrobial use and the FDA has removed all tylosin products used solely to treat tear-staining from the market.
Formulations Available within the OSU Pharmacy
- Tylosin 200mg/ml injectable suspension
- Tylan 200mg/ml injectable suspension
- Tylan soluble per gram
Notes
- Erythromycin is used to predict susceptibility.
