Reference Tables
Selected Antimicrobials and Restriction Status
Restriction Status Key
- Unrestricted
- Selectively Use: These antibiotics should NOT be used as empirical or first-line treatment. They should be used only when culture/sensitivity testing indicates they will be effective and other agents are inappropriate and/or ineffective. Approval does not need to be obtained from the Antimicrobial Stewardship Working Group prior to use of Selectively Use antimicrobials.
- Protected: Approval must be obtained from the Antimicrobial Stewardship Working Group prior to use of protected antimicrobials.
- Permitted ELDU (extra-label drug use): Use of an approved drug in a manner that is not in accordance with the approved labeling, yet meets the conditions set forth by AMDUCA and FDA regulations; includes use in another species, use for a different indication, use at a different dose or frequency, and use via a different route of administration. Consult specific drug page in this booklet as well as product labels to determine definitive contraindications to use.
- Prohibited ELDU
- Prohibited for Use in Food Animals
Restriction Status Reference Table
| Antimicrobial Name |
Companion Animal |
Equine | Major Species Intended for Food
(i.e. cattle, pigs, turkeys, chickens) |
Minor Food Species and Non-Food Animals
(i.e. camelids, all species that are not major species listed above): |
|---|---|---|---|---|
| Amikacin | Unrestricted | Unrestricted | (Including other Aminoglycosides)
Prohibited for Use in Food Animals 1 |
Unrestricted |
| Amoxicillin | Unrestricted | Unrestricted | ||
| Amoxicillin-Clavulanic Acid | Unrestricted | Permitted ELDU | Unrestricted | |
| Ampicillin | Unrestricted | Unrestricted | Permitted ELDU | Unrestricted |
| Ampicillin-Sulbactam | Unrestricted | Permitted ELDU | Unrestricted | |
| Azithromycin | Unrestricted | Unrestricted | Unrestricted | |
| Cefadroxil | Unrestricted | Unrestricted | ||
| Cefazolin | Unrestricted | Unrestricted | Unrestricted | |
| Cefotaxime | Unrestricted | Unrestricted | Unrestricted | |
| Cefovecin | Unrestricted | |||
| Cefoxitin | Unrestricted | |||
| Cefpodoxime | Unrestricted | Unrestricted | Unrestricted | |
| Ceftazidime | Selectively Use | Unrestricted | ||
| Ceftiofur | Unrestricted | Permitted ELDU 2 | Unrestricted | |
| Cephalexin | Unrestricted | Unrestricted | ||
| Cephapirin | Permitted ELDU 2 | |||
| Ciprofloxacin | Unrestricted | Unrestricted | ||
| Chloramphenicol | Unrestricted | Unrestricted | Prohibited for Use in Food Animals | Unrestricted |
| Clarithromycin | Unrestricted | |||
| Clindamycin | Unrestricted | Unrestricted | ||
| Doxycycline | Unrestricted | Unrestricted | Unrestricted | |
| Enrofloxacin | Unrestricted | Unrestricted | Prohibited ELDU | Unrestricted |
| Erythromycin | Unrestricted | Permitted ELDU | ||
| Florfenicol | Permitted ELDU | Unrestricted | ||
| Gentamicin | Unrestricted | Unrestricted | Prohibited for Use in Food Animals 1 | Unrestricted |
| Imipenem | Protected | Protected | ||
| Isoniazid | Selective Use | Selective Use | ||
| Lincomycin | Unrestricted | Unrestricted | ||
| Linezolid | Protected | Protected | ||
| Marbofloxacin | Unrestricted | Unrestricted | ||
| Meropenem | Protected | Protected | ||
| Metronidazole | Unrestricted | Unrestricted | Prohibited for Use in Food Animals | Unrestricted |
| Minocycline | Unrestricted | Unrestricted | ||
| Nitrofurantoin | Unrestricted | Prohibited for Use in Food Animals | Unrestricted | |
| Oxytetracycline | Unrestricted | Unrestricted | Permitted ELDU | Unrestricted |
| Penicillin | Unrestricted | Unrestricted | Permitted ELDU | Unrestricted |
| Piperacillin-tazobactam | Protected | |||
| Pradofloxacin | Selectively Use | Unrestricted | ||
| Rifampin | Unrestricted | Unrestricted | Unrestricted | |
| Sulfonamides | Unrestricted | Unrestricted | Permitted ELDU | Unrestricted |
| Tulathromycin | Permitted ELDU | |||
| Tylosin | Unrestricted | Permitted ELDU | ||
| Vancomycin | Protected | Protected | Prohibited for Use in Food Animals | Protected |
Footnotes
- Strongly discouraged, although not illegal, to use in animals intended for food. American Association of Bovine Practitioners (AABP) has a voluntary ban where practitioners promise not to use this class of antibiotic in cattle. (Back to Reference) ↩
- ELDU of ALL cephalosporin drugs, EXCEPT CEPHAPIRIN, is restricted in major food animal species (cattle, swine, turkeys, chickens). ELDU is permissible only for the therapeutic indications that are included on the product label (i.e. can use to treat conditions not specifically listed on the label). However, ELDU of cephalosporins (except Cephapirin) is PROHIBITED in situations where the intended use of the product deviates from the approved dose, treatment duration, frequency, and/or administration route on the product label as well as the intended use of a product in an unapproved major species or animal production class. In other words, it is permissible to use cephalosporin antibiotics to treat diseases not listed on the label, but you must use the labeled dose and route of administration in animals for which the drug has been approved. You may not use this class of antibiotics for growth promotion. (Back to Reference) ↩
