Selected Antimicrobial Information – Companion Animal
Linezolid [Companion]
Restriction Status
Protected
Dose
| Species | Usage | Dose |
|---|---|---|
| Cats | Treatment of multidrug resistant, Gram-positive infections causing life-threatening, systemic disease | 10mg/kg PO or IV q8-12h for 14d (extra-label use) |
| Dogs | Treatment of multidrug resistant, Gram-positive infections causing life-threatening, systemic disease | 10mg/kg PO or IV q8-12h for 14d (extra-label use) |
Brand Name(s)
Zyvox®
Background
Linezolid is a bacteriostatic, time-dependent oxazolidinone antibiotic with excellent activity against Gram-positive aerobes. Many Staphylococcus spp. and Enterococcus spp. that are resistant to other antimicrobials will be susceptible to linezolid; therefore, use should be strictly reserved for infections caused by organisms that are resistant to other antimicrobial choices. It is not effective against Gram-negative aerobes or anaerobes. Linezolid is well absorbed after ingestion. Distribution is fairly wide, but poor into bone or cerebral spinal fluid. Linezolid is primarily excreted as metabolites and some active drug in urine and feces. There is a post-antibiotic effect.
Acceptable Uses
- Treatment of multidrug resistant, Gram-positive infections causing life-threatening, systemic disease. Culture/susceptibility should be performed prior to use.
Unacceptable Uses
- Empiric use.
Formulations Available within the OSU Pharmacy
- Linezolid 600mg tablet
Notes
- Linezolid use in animals is highly controversial, and should only be considered as a last resort when other antimicrobial treatment options have been ruled out.
- Linezolid is on the protected antimicrobial list for the OSU-VMC, and approval must be obtained from the Antimicrobial Stewardship Working Group prior to prescribing.
