Selected Antimicrobial Information – Farm Animal
Penicillin [Farm Animal]
Restriction Status
Unrestricted
Dose
(Doses and indications may vary with brand name product. Consult product label.)
| Species | Usage | Dose |
|---|---|---|
| Camelids | Procaine Penicillin G | 22,000 IU/kg SQ q12h or 44,000 IU/kg SQ q24h (extra-label use) |
| Cattle | Procaine Penicillin G | 12,000 IU/kg IM q24h or 20,000 IU/kg IM q24h or 40,000 IU/kg IM q24h (extra-label use) |
| Penicillin G procaine + penicillin G benzathine combination | 12,000 – 40,000 IU/kg + 12,000 – 40,000 IU/kg IM twice, 48h apart | |
| Small Ruminants | For susceptible pathogens | 12,000 – 40,000 IU/kg IM q24h for no longer than 7d (extra-label use) |
| Swine | For susceptible pathogens | 12,000 – 40,000 IU/kg IM q24h for no longer than 7d (extra-label use) |
Brand Name(s)
procaine penicillin G, potassium penicillin G
Background
Penicillin G is a bactericidal, time-dependent β-lactam antibiotic with good activity against many Gram-positive aerobes and anaerobes, though it is not effective against β-lactamase-producing bacteria. It is also effective against spirochetes. There is limited efficacy against Gram-negative bacteria. Penicillin G distributes widely through the plasma but has low lipid solubility, and does not penetrate abscesses or sites of tissue necrosis well. The active form of penicillin G is excreted in high concentration in the urine.
Current Uses within OSU-VMC
- Treatment of bovine or small ruminant respiratory infections associated with Pasteurella spp. or other susceptible organisms.
- Treatment of swine respiratory infections associated with Pasteurella spp., Streptococcus spp., or other susceptible organisms.
- Treatment of clostridial infections.
- Treatment of swine erysipelas (diamond skin disease).
Contraindicated Uses
- Empirical treatment of suspected staphylococcal infections.
- Empirical treatment of suspected Enterobacteriaceae infections.
- Inactivated in the presence of purulent or necrotic material (e.g. abscesses).
Illegal Uses
- None
Formulations Available within the OSU Pharmacy
- Penicillin gel 5ml/syringe
- Penicillin G Potassium 20mmu injectable suspension
- Penicillin G Procaine injectable suspension (1 ml, 30 ml, 100 ml, 250 ml)
Notes
- Intravascular injection of procaine penicillin G can cause excitement, seizure-like activity, and death.
- Procaine penicillin G is labelled for IM administration only. If given by any other route of administration, the withdrawal time will need to be extended.
- Potassium penicillin is given IV.
