Selected Antimicrobial Information – Companion Animal

Cefadroxil [Companion]

Restriction Status



Species Usage Dose
Cats Label dose 22mg/kg PO q12h (dose q24h if there is renal impairment); duration of treatment not exceeding 21d
Dogs Label dose 22mg/kg PO q12h for 3-7d; duration of treatment not exceeding 30d
For pyoderma 22-35mg/kg PO q12h to resolution of clinical signs or one week past resolution (extra-label use)
For systemic or orthopedic infections 22mg/kg PO q8-12h for 30d (extra-label use)
11-12mg/kg PO q12h for 7-30d (extra-label use)

Brand Name(s)

Cefa-Drops®, Duricef®


Cefadroxil is a bactericidal, time-dependent first generation cephalosporin (β-lactam) antibiotic with activity primarily against Gram-positive aerobes, and more limited activity against Gram-negative aerobes. Activity against anaerobes is poor. Cefadroxil is not effective against Enterococcus spp., Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus spp. Distribution throughout the body is wide, but cefadroxil does not penetrate intracellularly or cross the blood-brain barrier. Excretion is primarily as active drug in urine.

Acceptable Uses

  • Treatment of susceptible skin (pyoderma), soft tissue, or orthopedic infections.
  • Treatment of susceptible respiratory infections, particularly those associated with Streptococcus or Staphylococcus spp.
  • Treatment of urinary tract infections.

Unacceptable Uses

  • N/A

Formulations Available within the OSU Pharmacy

  • No formulations currently available within the OSU pharmacy; will order upon request


  • Cefadroxil is longer-acting compared to other first generation cephalosporins, such as cephalexin.


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OSU VMC Antimicrobial Use Guidelines Copyright © 2018 by The Ohio State University College of Veterinary Medicine is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.