Selected Antimicrobial Information – Companion Animal
Cefadroxil [Companion]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Cats | Label dose | 22mg/kg PO q12h (dose q24h if there is renal impairment); duration of treatment not exceeding 21d |
| Dogs | Label dose | 22mg/kg PO q12h for 3-7d; duration of treatment not exceeding 30d |
| For pyoderma | 22-35mg/kg PO q12h to resolution of clinical signs or one week past resolution (extra-label use) | |
| For systemic or orthopedic infections | 22mg/kg PO q8-12h for 30d (extra-label use) | |
| For UTI |
11-12mg/kg PO q12h for 7-30d (extra-label use) |
Brand Name(s)
Cefa-Drops®, Duricef®
Background
Cefadroxil is a bactericidal, time-dependent first generation cephalosporin (β-lactam) antibiotic with activity primarily against Gram-positive aerobes, and more limited activity against Gram-negative aerobes. Activity against anaerobes is poor. Cefadroxil is not effective against Enterococcus spp., Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus spp. Distribution throughout the body is wide, but cefadroxil does not penetrate intracellularly or cross the blood-brain barrier. Excretion is primarily as active drug in urine.
Acceptable Uses
- Treatment of susceptible skin (pyoderma), soft tissue, or orthopedic infections.
- Treatment of susceptible respiratory infections, particularly those associated with Streptococcus or Staphylococcus spp.
- Treatment of urinary tract infections.
Unacceptable Uses
- N/A
Formulations Available within the OSU Pharmacy
- No formulations currently available within the OSU pharmacy; will order upon request
Notes
- Cefadroxil is longer-acting compared to other first generation cephalosporins, such as cephalexin.
