Selected Antimicrobial Information – Companion Animal

Cefovecin [Companion]

Restriction Status

Unrestricted

Dose

Species Usage Dose
Cats

Label dose 8mg/kg SQ once; therapeutic concentrations are maintained for approximately 7d
Treatment of periodontitis/gingivitis or UTI
Extra-label use
Dogs Label dose 8mg/kg SQ once; therapeutic concentrations are maintained for approximately 7-14d (dependent on organism)
Treatment of periodontitis/gingivitis or UTI Extra-label use

Brand Name(s)

Convenia®

Background

Cefovecin is a bactericidal, time-dependent third generation cephalosporin (╬▓-lactam) antibiotic with a long half-life. Activity against Gram-negative organisms is greater than first or second generation cephalosporins, but less compared to other third-generations cephalosporins. Activity against anaerobes is variable. It is not effective against Enterococcus spp., Pseudomonas aeruginosa, Bordetella bronchiseptica, and methicillin-resistant Staphylococcus spp. Distribution throughout the body is wide and excretion is primarily as active drug in urine.

Acceptable Uses

  • Treatment of skin infections (e.g. pyoderma, wounds, abscesses) associated with susceptible Staphylococcus pseudintermedius or Streptococcus canis in dogs, or Pasteurella multocida in cats.
  • When used in combination with mechanical cleaning, treatment of periodontitis or gingivitis.
  • Less preferred treatment for urinary tract infections when oral treatment is not possible.

Unacceptable Uses

  • Generally, less efficacious or ineffective at treating upper respiratory tract disease in cats and dogs.

Formulations Available within the OSU Pharmacy

  • Convenia 80mg/ml injectable suspension

Notes

  • Long-term excretion in urine (approximately 14d for dogs, 21d for cats) may make interpretation of post-treatment urine cultures difficult.

License

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OSU VMC Antimicrobial Use Guidelines Copyright © 2018 by The Ohio State University College of Veterinary Medicine is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.