Selected Antimicrobial Information – Equine

Meropenem [Equine]

Restriction Status

Protected

Dose

Use of this drug should be based on culture and sensitivity in consultation with the clinical microbiologist.

Brand Name(s)

Merrem® IV

Background

Meropenem is a bactericidal, time-dependent carbapenem (╬▓-lactam) antibiotic with broad-spectrum efficacy against Gram-positive aerobes, Gram-negative aerobes, and anaerobes. Many Enterobacteriaceae that are resistant to other antimicrobials will be susceptible to meropenem; therefore, use should be strictly reserved for infections caused by organisms that are resistant to other antimicrobial choices. Carbapenem resistance is a growing problem in human medicine and is expected to become an issue in veterinary medicine with time. Distribution of meropenem throughout the body is wide, and excretion is primarily in urine.

Acceptable Uses

  • N/A

Unacceptable Uses

  • Empirical treatment

Formulations Available within the OSU Pharmacy

  • Meropenem 1g/20ml injectable suspension
  • Meropenem 500mg/10ml injectable suspension

Notes

  • Meropenem use in animals is highly controversial and should only be considered as a last resort when all other antimicrobial treatment options have been ruled out.
  • Meropenem is on the protected antimicrobial list for the OSU-VMC, and approval must be obtained from the Antimicrobial Stewardship Working Group prior to prescribing.

License

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OSU VMC Antimicrobial Use Guidelines Copyright © 2018 by The Ohio State University College of Veterinary Medicine is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.