Selected Antimicrobial Information – Companion Animal
Clindamycin [Companion]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Cats |
Label dose | 11-33mg/kg PO q24h for no more than 14d |
| For skin or soft tissue infections | 11-33mg/kg PO or SQ q24h for 7-28d or 5-11mg/kg PO or SQ q12h for 7-28d (extra-label use) | |
| For sepsis |
10-15mg/kg IV q12h (extra-label use) | |
| For toxoplasmosis | 10-15mg/kg PO or IV q12h | |
| For dental prophylaxis/post-dental procedures | 5-10mg/kg PO q12h for 5-8d (extra-label use) | |
| Most commonly used dose range | 10-15mg/kg PO or IV q12h | |
| Dogs |
Label dose | 5.5-33mg/kg PO q12h for no more than 28d |
| For staphylococcal pyoderma | 11mg/kg PO or SQ q24h or 5.5mg/kg PO q12h to resolution of clinical signs or one week past resolution (extra-label use) | |
| For staphylococcal osteomyelitis | 11mg/kg PO q12h for 28-42d (q8h for anaerobic osteomyelitis) (extra-label use) | |
| For other wounds or abscesses, or dental infections |
11-33mg/kg PO, SQ, or IV q12h for 7-28d (extra-label use) | |
| For dental prophylaxis/post-dental procedures | 5-10mg/kg PO q12h for 5-8d (extra-label use) | |
| For sepsis | 10-15mg/kg IV q12h (extra-label use) | |
| For toxoplasmosis | 10-15mg/kg PO or IV q12h | |
| Most commonly used dose range | 10-15mg/kg PO or IV q12h |
Brand Name(s)
Antirobe®, Cleoncin®
Background
Clindamycin is a bacteriostatic, time-dependent lincosamide antibiotic with good activity against Gram-positive organisms such as Staphylococcus spp., and many anaerobes. It is not effective against most Gram-negative aerobes including Enterobacteriaceae and Pseudomonas aeruginosa, and Enterococcus spp. are also intrinsically resistant. Distribution is wide, including into bone and across inflamed meninges. Both unchanged drug and metabolites are excreted in urine, feces, and bile.
Acceptable Uses
- Treatment of staphylococcal pyoderma. Acceptable as an empiric treatment.
- Treatment of other skin infections including abscesses and wounds, including those with an anaerobic component (e.g. cat bite abscess).
- Treatment of dental infections or as dental prophylaxis. Most efficacious when used with mechanical dental cleaning.
- Treatment of staphylococcal or anaerobic osteomyelitis.
- In combination with an antimicrobial with Gram-negative coverage, empiric treatment of sepsis or bacteremia.
- First choice of treatment for toxoplasmosis in dogs and cats.
Unacceptable Uses
- Treatment of suspected or culture-confirmed Gram-negative infections.
- D-test (disk diffusion method using Clindamycin and Erythromycin disks) used to detect inducible Clindamycin resistance in Staphylococcus species.
Formulations Available within the OSU Pharmacy
- Clindamycin 25mg capsule
- Clindamycin 75mg capsule
- Clindamycin 150mg capsule
- Clindamycin 300mg capsule
- Clindamycin 25mg/ml oral suspension
- Clindamycin 150mg/ml injectable suspension
Notes
- N/A
