Selected Antimicrobial Information – Farm Animal
Ampicillin-Sulbactam [Farm Animal]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Camelids | Label dose | No labeled dose. |
| Cattle | Label dose | No labeled dose. |
| Small Ruminants | Label dose | No labeled dose. |
| Swine | Label dose | No labeled dose. |
Brand Name(s)
Unasyn®
Background
Ampicillin sodium-sulbactam sodium is a bactericidal, time-dependent β-lactam antibiotic with improved activity against Gram-negative organisms when compared to penicillin. The addition of sulbactam improves activity against β-lactamase-producing bacteria, such as Staphylococcus spp., though clavulanic acid is a more potent β-lactamase inhibitor. Activity against Gram-positive organisms is comparable to amoxicillin and ampicillin. Ampicillin-sulbactam distributes widely through the plasma, including into peritoneal and interstitial fluid. It does not penetrate abscesses or sites of tissue necrosis well. Excretion is primarily in urine.
Current Uses within OSU-VMC
- No labeled indications for food animals.
Contraindicated Uses
- None
Illegal Uses
- None
Formulations Available within the OSU Pharmacy
- Ampicillin/Sulbactam 1.5g (Ampicillin 1g/Sulbactam 0.5g)/vial injectable suspension
- Ampicilin/Sulbactam 3g (Ampicillin 2g/Sulbactam 1g)/vial injectable suspension
- Unasyn 1.5g/vial injectable suspension
- Unasyn 3g/vial injectable suspension
Notes
- Frequently used in extra-label fashion, ideal as a perioperative IV antimicrobial as it is broad-spectrum, water-soluble, and bactericidal.
