Selected Antimicrobial Information – Equine
Ceftiofur [Equine]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Horses |
Ceftiofur sodium (Naxcel®) |
|
| Ceftiofur crystalline free acid (Excede®) | For Streptococcus zooepidemicus: 6.6mg/kg IM at 0 and 96h |
Brand Name(s)
Excede®, Naxcel®
Background
Ceftiofur is a bactericidal, time-dependent third generation cephalosporin (β-lactam) antibiotic with a broad spectrum of activity against Gram-positive aerobes, Gram-negative aerobes including Enterobacteriaceae, and anaerobes including Clostridium spp. and Fusobacterium spp. It is not effective against Enterococcus spp. and Pseudomonas aeruginosa. Distribution throughout the body is wide, and includes penetration into joints and synovial fluid. Excretion is primarily in urine.
Acceptable Uses
- Treatment of respiratory infections caused by β-hemolytic streptococcal infections.
- Treatment of some abscesses, skin infections, or joint infections.
- Treatment of urinary tract infections.
- When used in combination with an aminoglycoside, can treat mixed infections where greater coverage against Gram-negative bacteria is required (sepsis, peritonitis, cholangiohepatitis, septic arthritis).
- Used in regional limb perfusion or intra-articular injection for treatment of septic arthritis.
Unacceptable Uses
- N/A
Formulations Available within the OSU Pharmacy
- Excede 200mg/ml injectable suspension
Notes
- A maximum of 10mL of Naxcel® or 20mL of Excede® should be given per injection site.
