Selected Antimicrobial Information – Companion Animal
Cefpodoxime [Companion]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Cats | Treatment of upper respiratory infections, urinary tract infections, pyoderma, or otitis media/interna | 5mg/kg PO q12h or 10mg/kg PO q24h for 5-7d or until infection is cleared (extra-label use) |
| Dogs | Label dose | 5-10mg/kg PO q24h for 5-7d, treatment not exceeding 28d |
Brand Name(s)
Simplicef®, Vantin®
Background
Cefpodoxime is a bactericidal, time-dependent third generation cephalosporin (β-lactam) antibiotic with excellent activity against Gram-negative bacteria such as Enterobacteriaceae. It is not effective against Enterococcus spp., Pseudomonas aeruginosa, methicillin-resistant Staphylococcus spp., or anaerobes. Distribution throughout the body is wide, but cefpodoxime does not penetrate intracellularly or cross the blood-brain barrier. Excretion is primarily in urine.
Acceptable Uses
- Treatment of upper respiratory infections, urinary tract infections, pyoderma, or otitis media/interna not responsive or resistant to other antimicrobial choices.
- As an oral alternative to cefotaxime.
Unacceptable Uses
- N/A
Formulations Available within the OSU Pharmacy
- Cefpodoxime 100mg tablet
- Cefpodoxime 200mg tablet
Notes
- Feline dosing recommendations are extrapolated from human data.
