Selected Antimicrobial Information – Companion Animal

Cefpodoxime [Companion]

Restriction Status

Unrestricted

Dose

Species Usage Dose
Cats Treatment of upper respiratory infections, urinary tract infections, pyoderma, or otitis media/interna 5mg/kg PO q12h or 10mg/kg PO q24h for 5-7d or until infection is cleared (extra-label use)
Dogs Label dose 5-10mg/kg PO q24h for 5-7d, treatment not exceeding 28d

Brand Name(s)

Simplicef®, Vantin®

Background

Cefpodoxime is a bactericidal, time-dependent third generation cephalosporin (╬▓-lactam) antibiotic with excellent activity against Gram-negative bacteria such as Enterobacteriaceae. It is not effective against Enterococcus spp., Pseudomonas aeruginosa, methicillin-resistant Staphylococcus spp., or anaerobes. Distribution throughout the body is wide, but cefpodoxime does not penetrate intracellularly or cross the blood-brain barrier. Excretion is primarily in urine.

Acceptable Uses

  • Treatment of upper respiratory infections, urinary tract infections, pyoderma, or otitis media/interna not responsive or resistant to other antimicrobial choices.
  • As an oral alternative to cefotaxime.

Unacceptable Uses

  • N/A

Formulations Available within the OSU Pharmacy

  • Cefpodoxime 100mg tablet
  • Cefpodoxime 200mg tablet

Notes

  • Feline dosing recommendations are extrapolated from human data.

License

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OSU VMC Antimicrobial Use Guidelines Copyright © 2018 by The Ohio State University College of Veterinary Medicine is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.