Selected Antimicrobial Information – Equine

Cefpodoxime [Equine]

Restriction Status



Species Usage Dose
For susceptible infections in neonatal foals 10mg/kg PO q6-12h (extra-label use)

Brand Name(s)

Simplicef®, Vantin®


Cefpodoxime is a bactericidal, time-dependent third generation cephalosporin (╬▓-lactam) antibiotic with excellent activity against Gram-negative bacteria such as Enterobacteriaceae. It is not effective against Enterococcus spp. or Pseudomonas aeruginosa. Distribution throughout the body is wide, but cefpodoxime does not penetrate intracellularly or cross the blood-brain barrier. Excretion is primarily in urine.

Acceptable Uses

  • Oral alternative to cefotaxime for treatment of sepsis in neonatal foals; culture/susceptibility should be performed to further guide treatment.

Unacceptable Uses

  • N/A

Formulations Available within the OSU Pharmacy

  • Cefpodoxime 100mg tablet
  • Cefpodoxime 200mg tablet


  • None.


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