Selected Antimicrobial Information – Equine

Cefpodoxime [Equine]

Restriction Status

Unrestricted

Dose

Species Usage Dose
Horses
For susceptible infections in neonatal foals 10mg/kg PO q6-12h (extra-label use)

Brand Name(s)

Simplicef®, Vantin®

Background

Cefpodoxime is a bactericidal, time-dependent third generation cephalosporin (╬▓-lactam) antibiotic with excellent activity against Gram-negative bacteria such as Enterobacteriaceae. It is not effective against Enterococcus spp. or Pseudomonas aeruginosa. Distribution throughout the body is wide, but cefpodoxime does not penetrate intracellularly or cross the blood-brain barrier. Excretion is primarily in urine.

Acceptable Uses

  • Oral alternative to cefotaxime for treatment of sepsis in neonatal foals; culture/susceptibility should be performed to further guide treatment.

Unacceptable Uses

  • N/A

Formulations Available within the OSU Pharmacy

  • Cefpodoxime 100mg tablet
  • Cefpodoxime 200mg tablet

Notes

  • None.

License

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OSU VMC Antimicrobial Use Guidelines Copyright © 2018 by The Ohio State University College of Veterinary Medicine is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.