Selected Antimicrobial Information – Equine
Ampicillin [Equine]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Horses |
For treatment of streptococcal lower airway infections or neonatal sepsis. |
|
Brand Name(s)
Polyflex®
Background
Ampicillin is a bactericidal, time-dependent β-lactam antibiotic with improved activity against Gram-negative organisms when compared to penicillin, though with somewhat less activity against Gram-positive organisms. Ampicillin distributes widely through the plasma and can cross the blood-brain barrier when meninges are inflamed. It does not penetrate abscesses or sites of tissue necrosis well. Excretion is primarily in urine.
Acceptable Uses
- When used in combination with amikacin (an aminoglycoside), for treatment of neonatal sepsis.
- For treatment of streptococcal lower airway infections.
- Can be used as IV an alternative to penicillin in most cases.
Unacceptable Uses
- Inactivated in the presence of purulent or necrotic material (e.g. abscesses).
- Empirical treatment of suspected staphylococcal infections.
- In combination with a bacteriostatic antimicrobial, efficacy is decreased.
Formulations Available within the OSU Pharmacy
- Ampicillin 1g/vial injectable suspension
- Ampicillin 500mg/vial injectable suspension
- Ampicillin Na 1g/vial injectable suspension
- Ampicillin Na 500mg/vial injectable suspension
Notes
- Ampicillin trihydrate (Polyflex®) should not be given IV due to risk of anaphylaxis and sudden death. Ampicillin sodium is safe for IV injection.
