Selected Antimicrobial Information – Equine
Enrofloxacin [Equine]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Horses |
For treatment of susceptible infections |
|
Brand Name(s)
Baytril®
Background
Enrofloxacin is a bactericidal, concentration-dependent fluoroquinolone antibiotic with activity primarily against Gram-negative aerobes, such as Enterobacteriaceae and Pseudomonas aeruginosa. Gram-positive coverage is limited, though enrofloxacin is efficacious against many Staphylococcus spp. Distribution is wide, including into abscesses, and excretion is primarily in the urine with also a lesser component of biliary excretion.
Acceptable Uses
- Treatment of Gram-negative infections, or when combined with a β-lactam antibiotic, broad spectrum antimicrobial coverage. This includes Gram-negative pneumonia, osteomyelitis, or septic arthritis.
- Treatment of intracellular infections, such as Mycoplasma, Neorickettsia, or Anaplasma.
- Treatment of internal abscesses, such as Corynebacterium pseudotuberculosis infections.
- Treatment of urinary tract infections.
Unacceptable Uses
- Gram-positive infections other than susceptible Staphylococcus spp.
- Anaerobic infections.
- Should not be used in foals due to risk of articular cartilage damage.
Formulations Available within the OSU Pharmacy
- Enrofloxacin 100mg/ml injectable suspension
- Enrofloxacin 20mg/ml oral suspension
- Enrofloxacin 22.7mg tablet
- Enrofloxacin 68mg tablet
- Enrofloxacin 136mg tablet
- Baytril 22.7mg/ml injectable suspension
- Baytril 100mg/ml injectable suspension
- Baytril 22.7mg tablet
- Baytril 68mg tablet
Notes
- Formulations given PO have been associated with oral ulceration and/or colitis.
- Ciprofloxacin has been associated with fatal colitis in horses and should not be used.
