Selected Antimicrobial Information – Equine
Cefotaxime [Equine]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Horses |
For susceptible infections in neonatal foals | 20-40mg/kg IV q6-12h (extra-label use) |
| For meningitis in neonatal foals | 40mg/kg IV q6h (extra-label use) | |
| For regional limb perfusion in foals | 1g per 20mL 0.9% NaCl for 20min (extra-label use) |
Brand Name(s)
Claforan®
Background
Cefotaxime is a bactericidal, time-dependent third generation cephalosporin (β-lactam) antibiotic with increased activity against Gram-negative bacteria such as Enterobacteriaceae when compared to first and second generation cephalosporins (e.g. cefazolin). It is not effective against Enterococcus spp. and Pseudomonas aeruginosa, and has less efficacy against anaerobes than second generation cephalosporins. Distribution throughout the body is wide, and cefotaxime crosses the blood-brain barrier. Excretion is primarily in urine.
Acceptable Uses
- Empirical treatment of sepsis or meningitis in neonatal foals; culture/susceptibility should be performed to further guide treatment.
- Treatment of susceptible septic arthritis in foals.
Unacceptable Uses
- N/A
Formulations Available within the OSU Pharmacy
- Cefotaxime 10g/100ml injectable suspension
Notes
- None.
