Selected Antimicrobial Information – Companion Animal
Rifampin [Companion]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Cats |
For bartonellosis | 5-10mg/kg PO q24 for 14d (can be used up to 20mg/kg) (extra-label use) |
| Dogs |
For pyoderma | 10mg/kg PO q24h (extra-label use) |
| For bacteremia | 10mg/kg IV or IM q12h (extra-label use) | |
| For brucellosis | 5-10mg/kg PO q24h (extra-label use) |
Brand Name(s)
Rifampicin®, Rifadin®
Background
Rifampin is a bactericidal, concentration-dependent antibiotic with a narrow spectrum of activity against Gram-positive aerobes such as Staphylococcus spp., some non-enteric Gram-negative aerobes such as Bartonella or Brucella, and most anaerobes. Distribution is wide, including intracellularly, and rifampin remains active in acidic environments such as necrotic tissue. Excretion is not fully understood, but is thought to be primarily in bile.
Acceptable Uses
- Treatment of refractory pyoderma, abscesses, or other soft tissue infections. Particularly useful for methicillin-resistant Staphylococcus infections.
- Treatment of osteomyelitis or implant infections, CNS infections, infectious endocarditis, and other hard-to-reach sites. Particularly useful for methicillin-resistant Staphylococcus infections.
Unacceptable Uses
- Not for use as a first-line antimicrobial choice. Culture/susceptibility testing are highly recommended.
Formulations Available within the OSU Pharmacy
- Rifampin 300mg capsule
Notes
- May affect elimination of other hepatically-metabolized drugs (e.g. barbituates).
- Causes orange to red staining of mucous membranes, urine, and other secretions.
