Selected Antimicrobial Information – Companion Animal
Ampicillin-Sulbactam [Companion]
Restriction Status
Unrestricted
Dose
| Species | Usage | Dose |
|---|---|---|
| Cats |
For susceptible infections | 10-20mg/kg IV or IM q8h, given slowly (extra-label use) |
| As part of a treatment regimen for sepsis |
30mg/kg IV q6-8h (extra-label use) | |
| As a CRI |
3.75-8.3mg/kg/hr (extra-label use) | |
| Dogs |
For susceptible infections | 10-20mg/kg IV or IM q8h, given slowly (extra-label use) |
| As part of a treatment regimen for sepsis | 30mg/kg IV q6-8h (extra-label use) | |
| As a CRI | 3.75-8.3mg/kg/hr (extra-label use) |
Brand Name(s)
Unasyn®
Background
Ampicillin sodium-sulbactam sodium is a bactericidal, time-dependent β-lactam antibiotic with improved activity against Gram-negative organisms when compared to penicillin. The addition of sulbactam improves activity against β-lactamase-producing bacteria, such as Staphylococcus spp., though clavulanic acid is a more potent β-lactamase inhibitor. Activity against Gram-positive organisms is comparable to amoxicillin and ampicillin. Ampicillin-sulbactam distributes widely through the plasma, including into peritoneal and interstitial fluid. It does not penetrate abscesses or sites of tissue necrosis well. Excretion is primarily in urine.
Acceptable Uses
- Treatment of infections susceptible to amoxicillin-clavulanic acid in patients unable to tolerate oral medication.
- Treatment of soft tissue or orthopedic infections.
- Treatment of genitourinary infections.
- Treatment of intra-abdominal infections.
- In combination with an aminoglycoside or fluoroquinolone, part of broad-spectrum therapy for sepsis or other critical systemic infections.
- As a parenteral alternative to amoxicillin-clavulanic acid.
Unacceptable Uses
- N/A
Formulations Available within the OSU Pharmacy
- Ampicillin/Sulbactam 1.5g (Ampicillin 1g/Sulbactam 0.5g)/vial injectable suspension
- Ampicilin/Sulbactam 3g (Ampicillin 2g/Sulbactam 1g)/vial injectable suspension
- Unasyn 1.5g/vial injectable suspension
- Unasyn 3g/vial injectable suspension
Notes
- N/A
