Selected Antimicrobial Information – Farm Animal
Ceftiofur [Farm Animal]
Restriction Status
N/A
Dose
Ceftiofur HCl (Excenel®, Spectramast®)
| Species | Usage | Dose |
|---|---|---|
| Camelids | For metritis, interdigital necrobacillosis (foot rot), pododermatitis and neonatal sepsis | 1.1-2.2mg/kg IM or SQ q12-24h (extra-label) |
| Cattle | Label dose | 1.1-2.2mg/kg IM or SQ for 3-5d (4-5d for respiratory disease, 5d for acute metritis); do not give more than 15mL per injection site |
| For subclinical staphylococcal or streptococcal mastitis | Infuse one syringe of Spectramast® into affected quarter at dry off | |
| For clinical mastitis in lactating dairy cattle | Infuse one syringe of Spectramast® into the affected quarter, repeat q24h for up to 8d | |
| Small Ruminants | N/A | N/A |
| Swine | Label dose | 3-5 mg/kg IM q24h for 3d |
Ceftiofur crystalline free acid (Excede®)
| Species | Usage | Dose |
|---|---|---|
| Camelids | For metritis, interdigital necrobacillosis (foot rot), pododermatitis and neonatal sepsis | 6.6mg/kg SQ once (extra-label) |
| Cattle | For acute metritis ONLY | 6.6mg/kg SQ once in the base of the ear, repeat in 72h |
| Small Ruminants | N/A | N/A |
| Swine | For respiratory disease | 5.0mg/kg IM once in the post-auricular region; do not give more than 2mL per injection site |
Ceftiofur sodium (Naxcel®, Ceftiflex®)
| Species | Usage | Dose |
|---|---|---|
| Camelids | For metritis, interdigital necrobacillosis (foot rot), pododermatitis and neonatal sepsis | 1.1-2.2mg/kg IM, or SQ q24 for 3-5d (extra-label) |
| Cattle | Label dose | 1.1-2.2mg/kg IM or SQ q24h for 3-5d |
| Small Ruminants | For metritis, respiratory disease, interdigital necrobacillosis (foot rot), pododermatitis and neonatal sepsis | 1.1-2.2mg/kg IM q24h for 3d |
| Swine | Label dose | 3-5mg/kg IM q24h for 3d |
Brand Name(s)
Excenel®, Spectramast®, Excede®, Naxcel®, Ceftiflex®
Background
Ceftiofur is a bactericidal, time-dependent third generation cephalosporin (β-lactam) antibiotic with a broad spectrum of efficacy against Gram-positive bacteria, Gram-negative bacteria including Enterobacteriaceae, and anaerobes including Clostridium spp. and Fusobacterium spp. Distribution throughout the body is wide, including penetration into joints and synovial fluid. Excretion is primarily in the urine.
Current Uses within OSU-VMC
- Treatment of bovine or small ruminant respiratory disease associated with Mannheimia spp., Pasteurella spp., Histophilus spp., or other susceptible organisms.
- Treatment of swine respiratory disease associated with Actinobacillus spp., Pasteurella spp., Haemophilus spp., Streptococcus suis, or Salmonella cholerasuis.
- Treatment of acute post-partum (0-14d) bacterial metritis in cattle, small ruminants, or camelids.
- Treatment of interdigital necrobacillosis (foot rot) or pododermatitis.
- Treatment of subclinical mastitis at time of dry off or clinical mastitis in lactating dairy cattle, typically caused by Staphylococcus spp., Streptococcus spp., or Escherichia coli.
- Treatment of neonatal sepsis.
Contraindicated Uses
- Ceftiofur is permitted for use for indications not specified on the label but must not be used at any dose, frequency/duration, or route of administration other than as specified on the label.
Illegal Uses
- None
Formulations Available within the OSU Pharmacy
- Excenel 50mg/ml injectable suspension
- Spectramast DC 500mg/10ml intra-mammary suspension
- Spectramast LC 125mg/10ml intra-mammary suspension
- Excede 200mg/ml injectable suspension
- Excede Swine 100mg/ml injectable suspension
- Naxcel 1g/vial (20ml) injectable suspension
- Naxcel 4g/vial (80ml) injectable suspension
Notes
- IV injection of ceftiofur crystalline free acid may result in death.
- There are 2 Spectramast® products (LC and DC): LC is a lactating cow formulation and DC is for cows at dry off.
