Selected Antimicrobial Information – Farm Animal

Oxytetracycline [Farm Animal]

Restriction Status

Unrestricted

Dose

(Doses and indications may vary with brand name product. Consult product label.)

Species Usage Dose
Camelids For susceptible pathogens
  • 10mg/kg IV q12-24h (extra-label use)
  • 20mg/kg IM or SQ q24-72h (extra-label use)
Cattle Oxytetracycline 200mg/mL (e.g. Liquamycin-200®, Bio-Mycin-200®) Label dose for pneumonia 20mg/kg SQ, IV, or IM once
Oxytetracycline 200mg/mL (e.g. Liquamycin-200®, Bio-Mycin-200®) Label dose for other indications 6.6-11mg/kg SQ, IV, or IM q24h for up to 4d
Oxytetracycline 300mg/mL (e.g. Tetradure-300®) Label dose for pneumonia or pink eye 20-30mg/kg IM or SQ once
Oxytetracycline 300mg/mL (e.g. Tetradure-300®) Label dose for other indications 6.6-11mg/kg IM, SQ, or IV (given slowly) q24h for no more than 4d
Oxytetracycline 300mg/mL (e.g. Tetradure-300®) for combination products with flunixin (e.g. Hexasol®) 30mg/kg IM or SQ once; do not give more than 10mL per injection site
Small Ruminants For susceptible pathogens
  • 10mg/kg IV or IM q12-24h
  • Long-acting formulas: 20mg/kg IM q48-72h
Swine Tetradure-300® Label dose
  • 20mg/kg IM once
  • 6.6-11mg/kg IM q24h for up to 4d

Brand Name(s)

Bio-Mycin® 200, Liquamycin (LA)-200®, Tetradure-300®, Hexasol, Terramycin® ointment, etc.

Background

Oxytetracycline is a time-dependent, bacteriostatic tetracycline antibiotic with a broad spectrum of activity against many Gram-positive and Gram-negative aerobes. It is not effective against Proteus spp. or Pseudomonas spp. Efficacy against clostridial organisms is variable. Intracellular organisms are highly susceptible. Distribution is widespread, but oxytetracycline does not enter the central nervous system. Oxytetracycline undergoes entero-hepatic recycling and is primarily excreted in the urine.

Current Uses within OSU-VMC

  • Treatment of bovine or small ruminant respiratory disease associated with susceptible Pasteurella spp., Mannheimia spp., Histophilus spp., or Haemophilus spp., or calf diphtheria.
  • Treatment of swine respiratory disease associated with susceptible Pasteurellaceae spp.
  • Treatment of infectious bovine keratoconjunctivitis (pinkeye) associated with Moraxella bovis.
  • Treatment of interdigital necrobacillosis (foot rot) or pododermatitis.
  • Treatment enteritis (scours) in calves, small ruminants, and swine.
  • Treatment of Wooden Tongue (Actinobacillus lignieresii).
  • Treatment of leptospirosis in cattle and swine.
  • Treatment of acute metritis or wound infections associated with Streptococcus or Staphylococcus spp.
  • Treatment of in the face of an abortion outbreak in ewes associated with Chlamydophila spp., Campylobacter spp., or Coxiella burnetii.

Contraindicated Uses

  • None

Illegal Uses

  • None

Formulations Available within the OSU Pharmacy

  • Oxytetra 100mg/ml injectable suspension
  • Oxytetra 200 mg/ml injectable suspension

Notes

  • None.

License

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OSU VMC Antimicrobial Use Guidelines Copyright © 2018 by The Ohio State University College of Veterinary Medicine is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.